BGP-15 dihydrochloride
(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
CAS: 66611-37-8
Molecular Formula: C14H22N4O2
BGP-15 dihydrochloride - Names and Identifiers
| Name | (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide |
| Synonyms | BGP15 BGP 15 BGP-15 CS-2406 BGP-15 HCl BGP-15 2HCl BGP-15 dihydrochloride (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide N-(2-Hydroxy-3-(piperidin-1-yl)propoxy)-nicotinimidamide dihydrochloride (Z)-N'-(2-Hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide dihydrochloride |
| CAS | 66611-37-8 |
BGP-15 dihydrochloride - Physico-chemical Properties
| Molecular Formula | C14H22N4O2 |
| Molar Mass | 278.35008 |
| Solubility | Soluble in Water (70 mg/ml) |
| Appearance | solid |
| Color | Off-white |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month. |
| In vitro study | Hydroxylamine derivative BGP-15 is a co-inducer of HSP72 in vitro, but is effective only when co-treated with heat shock and has no effect on HSP90 levels. BGP-15 (200 μm) can prevent imatinib mesylate-induced oxidative damage, reduce the loss of high-energy phosphate compounds, and change the signaling pathway effect of imatinib mesylate by preventing the activation of p38 MAPK and JNK, phosphorylation of Akt and GSK-3beta was induced. The inhibitory effect of BGP-15 on the activation of p38 and JNK is very significant, because these kinases contribute to cell death and inflammatory response in the isolated perfused heart. |
| In vivo study | BGP-15 improved heart function and reduced arrhythmia in two mouse models of heart failure and atrial fibrillation, respectively. Prior to cisplatin treatment, the development of cisplatin-induced acute renal failure was prevented or significantly inhibited by oral administration of BGP-15 mg/kg. Of the cisplatin-induced nephrotoxicity, BGP-15 had a significant effect on the renal antioxidant response. It increased the decrease of glutathione and catalase in water, but had no effect on SOD activity. BGP-15 treatment reduced cisplatin-induced ROS production and restored high-energy phosphate compound intermediate levels. Although BGP-15 protects the kidney from nephrotoxicity, it does not attenuate the anti-tumor effects of cytostatic agents. BGP-15 can improve the survival rate of P-388 leukemia mice treated with cisplatin. BGP-15 inhibits cisplatin-induced ADP-ribose polymerization in the kidney. At the same time, BGP-15 can restore cisplatin-induced energy metabolism disorder and maintain ATP levels in their protected tissues. |
BGP-15 dihydrochloride - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
BGP-15 dihydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.593 ml | 17.963 ml | 35.926 ml |
| 5 mM | 0.719 ml | 3.593 ml | 7.185 ml |
| 10 mM | 0.359 ml | 1.796 ml | 3.593 ml |
| 5 mM | 0.072 ml | 0.359 ml | 0.719 ml |
Last Update：2024-01-02 23:10:35
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Product Name: (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Visit Supplier Webpage Request for quotation
CAS: 66611-37-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 66611-37-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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